July  16, 2024 | 4-5.30 pm

Transforming the care of patients with complex inflammatory bowel disease.

Genomic analysis is a foundation of precision medicine. With a better understanding of the molecular causes of inflammatory bowel diseases (IBD) and enteropathies there are therapeutic opportunities. Increasingly there is realisation of a spectrum of disease where multifactorial and polygenic Crohn’s disease, ulcerative colitis, and IBD unclassified, is complemented by monogenic conditions that can present with intestinal inflammation. For those exceptionally rare monogenic conditions, the NHS has commissioned genomic testing. The diagnostic challenge is to select those patients who might benefit from genomic medicine, to interpret the genetic results, validate the findings and select evidence-based treatments.The successful implementation and progression of clinical genomics requires multi-disciplinary care, specialist knowledge and establishment of professional networks. The monogenic IBD grand round series, aims to discuss diagnostics and clinical care for patients with suspected or confirmed monogenic IBD supporting practical implementation of clinical genomics in paediatric and adult IBD.

Aim is to discuss genetics, immunology, endoscopy, histology, and treatment of complex patients challenging mIBD patients where a clear learning objective is achieved or a national specialist input might be helpful (England, Scotland, Wales, NI). Themonogenic IBD grand round is a clinical and educational forum to bridge and support ongoing multi-disciplinary care discussions and specialised clinics in each region.

Audience: Paediatric and adult gastroenterologists, immunologists, geneticists, SHO and registrars / trainees. 

Please send suggestions for presentation until 25th June 2024 to holm.uhlig@ndm.ox.ac.uk

Name of the presenter and co-presenter and hospital:

Patient history background (all strictly anonymised)

Patient phenotype (including age of IBD onset, extraintestinal manifestations, previous/current treatments):

Family history:
Genetic investigations and genotype:
Immunological tests and key results:
Discussion, recommendation for patient care and key questions:

3-4 presentations will be selected. This is an opportunity to present for trainees and receive mentoring from specialists in the field.