This is a new initiative which is under development and will come online soon.
It is proposed the WGs on BSPGHAN put a list together with links to significant new publications from the previous months. Where copyright allows we will post the actual paper, but more usually it is anticipated that this will be a link. Should be a useful resource for trainees to use for Journal Club but also for those amongst us who are so busy that we sometimes miss an outstanding publication. I hope that all the chairs of the BSPGHAN WGs will suggest papers so that our education / CME base remains broad.
Council is working on the mechanics of this but I hope we shall see it soon.
Here is a link of immense importance to the very few members of the Society who work purely in motility, but it’s a really tantalising paper worthy of discussion in the context of in house journal clubs (I hope you agree)!
The Diverse Phenotype of Intestinal Dysmotility Secondary to ACTG2-related Disorders
DOI: 10.1097/MPG.0000000000003400
Abstract
Background and Aims:
The initial description of a heterozygous dominant ACTG2 variant in familial visceral myopathy was followed by the identification of additional variants in other forms of intestinal dysmotility disorders. we aimed to describe the diverse phenotype of this newly reported and rare disease.
Methods:
Report of 4 new patients, and a systematic review of ACTG2-related disorders. we analyzed the population frequency and used in silico gene damaging predictions. Genotype-phenotype correlations were explored.
Results:
One hundred three patients (52% girls), from 14 publications, were included. Twenty-eight unique variants were analyzed, all exceedingly rare, and 27 predicted to be highly damaging. The median Combined Annotation Dependent Depletion (CADD) score was 29.2 (Interquartile range 26.3–29.4). Most patients underwent abdominal surgery (66%), about half required intermittent bladder catheterization (48.5%), and more than half were parenteral nutrition (PN)-dependent (53%). One-quarter of the patients died (25.7%), and 6 required transplant (5.8%). Girls had a higher rate of microcolon (P= 0.009), PN dependency (P = 0.003), and death/transplant (P = 0.029) compared with boys, and early disease onset (<2 years of age) was associated with megacystis-microcolon-intestinal hypoperistalsis syndrome (MMIHS) features. There was no statistical association between disease characteristics and CADD scores.
Conclusions:
Damaging ACTG2 variants are rare, often associated with MMIHS phenotype, and overall have a wide phenotypic variation. Symptoms usually present in the perinatal period but can also appear at a later age. The course of the disease is marked by frequent need for surgical interventions, PN support, and mortality. Poor outcomes are more common among girls with ACTG2 variants.
March 2025 Journal Scan
PDFs:
- Clinical Outcomes of Percutaneous Transhepatic Biliary Drainage in Pediatric Patients following Liver Transplantation
- Comparing the Effect of Oil Massage on Phototherapy Efficacy in Term Neonates with Hyperbilirubinemia: A Randomized Controlled Trial
- Impact of ESPGHAN no-biopsy strategy on the outcome of celiac disease treatment in children
- Prevalence and trend of anemia in children with inflammatory bowel disease: A national register‐based cohort study
- Effects of lipid‐based nutrient supplements on gut markers in stunted children: Secondary analysis of a randomised trial
- Proctocolitis or TikTok‐olitis: The dangers of social media influence on home constipation management
- Red cell distribution width as a predictor of outcome in acute pancreatitis in Children
- Therapeutic Effect of Table Salt on Gastrostomy Granulomas in Pediatric Patients: A Prospective Study
Word Documents:
- Colonic transit studies and colonic manometry in pediatric constipation
- Effect of bovine colostrum supplementation on gut health of children: A systematic review
- Efficacy of anal botulinum toxin injection in children with functional constipation
- Hepatic venous wedge pressure gradient measurements in intestinal failure associated liver disease
- Mast cells and corticotropin-releasing hormone receptors in duodenal tissue of children with functional dyspepsia
- Recommendations from the European guidelines for the diagnosis and therapy of pancreatic exocrine insufficiency
- Safety and efficacy of adalimumab 40 mg every 3 weeks in pediatric-onset Crohn’s disease
- Technical review by the ESPGHAN special interest group on gut microbiota and modifications on the health outcomes of infant formula supplemented with manufactured human milk oligosaccharides
- Technical review by the ESPGHAN Special Interest Group on Gut Microbiota and Modifications on the health outcomes of infant formula supplemented with synbiotic
- Vitamin D status in children undergoing allogeneic hematopoietic stem cell transplantation: A prospective exploratory study
January 2025 Journal Scan
PDFs:
- Prevention of refeeding syndrome: Evaluation of an enteral refeeding protocol for severely undernourished children
- Prevalence of functional defecation disorders in European children: A systematic review and meta‐analysis
- Approach to anaemia in gastrointestinal disease: A position paper by the ESPGHAN Gastroenterology Committee
- Evaluation and management of pediatric refractory constipation: Recommendations from the NASPGHAN neurogastroenterology and motility committee
- Long‐term growth and nutrition outcomes in children following intestinal transplantation
- Primary sclerosing cholangitis in children with inflammatory bowel disease: An ESPGHAN position paper from the Hepatology Committee and the IBD Porto group
- Significance and Related Factors of Helicobacter pylori Infection in Children with Dyspepsia
Word Documents:
- Burkitt lymphoma in a child with rectal bleeding
- Food access and the severity of newly diagnosed pediatric inflammatory bowel disease
- Helicobacter pylori infection is associated with significant elevations to fecal calprotectin, systemic inflammatory markers
- Identifying risk factors for vomiting during diarrhea: A secondary analysis of a randomized trial of zinc supplementation
- Impact of diagnostic testing on outcomes of children with rumination syndrome
- Management of pediatric Peutz–Jeghers syndrome: Highlighting the efficacy and safety of endoscopic ischemic polypectomy
December 2024 Journal Scan
PDFs:
- Long‐term outcome of pediatric acute severe colitis: A prospective 5‐year follow‐up of the PRASCO trial
- Sleep duration among breastfed, goat milk‐based or cow’s milk‐based infant formula‐fed infants: Post hoc analyses from a double‐blind RCT
- Comparison of colonoscopic versus fluoroscopic colonic manometry catheter placement in children
- Intestinal histopathology in pediatric PSC‐IBD: Characterization of phenotype and assessment of the Nancy Index
- Prevalence and sequelae of asymptomatic Clostridioides difficile colonization in children with inflammatory bowel disease
- Serum bile acids early after portoenterostomy are predictive for native liver survival and portal hypertension in biliary atresia
- Towards a common approach for managing food allergy and serious allergic reactions (anaphylaxis) at school. GA2 LEN and EFA consensus statement
- European guidelines for the diagnosis and treatment of pancreatic exocrine insufficiency: UEG, EPC, EDS, ESPEN, ESPGHAN, ESDO, and ESPCG evidence‐based recommendations
Word Documents:
- Diagnostic characteristics of pediatric cyclic vomiting syndrome
- How do we define normal bowel frequency from newborn to teens?: A Bayesian meta-analysis
- Intestinal ultrasound at diagnosis of pediatric inflammatory bowel disease compared to endoscopy
- Evaluation and management of pediatric refractory constipation: Recommendations from the NASPGHAN neurogastroenterology and motility committee
- Vitamin and trace element status and growth in children with short bowel syndrome being weaned off parenteral nutrition
- Youth With Functional Abdominal Pain Disorders Have More Sleep Disturbances. A School-Based Study
November 2024 Journal Scan
PDFs:
- Expression of IL-7RαlowCX3CR1+ CD8+ T Cells and α4β7 Integrin Tagged T Cells Related to Mucosal Immunity in Children with Inflammatory Bowel Disease
- A Small Device May Deliver King-Sized Solutions for Patients With an Exacerbation of Cystic Fibrosis
- Metabolic and bariatric surgery for adolescents with severe obesity: Benefits, risks, and specific considerations
- Dietary assessments in individuals living with coeliac disease: key considerations
- The evidence for probiotics in the treatment of digestive disorders in the pediatric population
- Direct cholangioscopy supporting diagnosis and conservative surgery of a biliary rhabdomyosarcoma in a child
- Incidence, diagnostics, therapeutic management and outcomes of paediatric intestinal pseudo‐obstruction in the Netherlands: A 20‐year retrospective cohort study
- Long‐term follow‐up of children with Crohn’s disease and small bowel mucosal lesions detected through video capsule endoscopy
- Removal of an ingested battery‐containing toothbrush that had caused esophageal obstruction in an 11‐month‐old male
- Impact of parenteral nutrition on quality of life, the family and gastrointestinal symptoms in children with intestinal failure
- Gastrointestinal involvement in Henoch–Schönlein purpura
- Prevalence and Factors associated with Bowel Dysfunctions after Pull-Through Surgery in Children Diagnosed with Hirschsprung Disease
- Heterogeneity of definition of upper gastrointestinal tract in different guidelines of Crohn’s disease: A scoping review
Word Documents:
- Analgesia in paediatric acute pancreatitis: A scoping systematic review
- Pharmacological management of pediatric metabolic dysfunction-associated steatotic liver disease
- Portal hypertension in doublecortin domain-containing protein 2 (DCDC2) related neonatal sclerosing cholangitis
- Upadacitinib is associated with clinical response and steroid-free remission for children and adolescents with inflammatory bowel disease
October 2024 Journal Scan
PDFs:
- EAACI guidelines on the management of IgE-mediated food allergy
- Effectiveness and safety of polyethylene‐glycol‐4000 versus sodium picosulphate plus magnesium oxide and citric acid for bowel cleansing before colonoscopy in children: A systematic review with meta‐analysis
- Integrating Evidence to Guide use of biologics and small molecules in IBD
- AGA Clinical Practice Update on Diet and Nutritional Therapies in Patients With Inflammatory Bowel Disease: Expert eview
- AGA Clinical Practice Guideline on Fecal Microbiota–Based Therapies for Select Gastrointestinal Diseases
- Congenital Diarrhoeas and Enteropathies
- Impact of acid blocker therapy on growth, gut microbiome, and lung disease in young children with cystic fibrosis
- Food insecurity impacts diet quality and adherence to the gluten‐free diet in youth with celiac disease
- Myointimal hyperplasia of the mesenteric veins mimicking inflammatory bowel disease in a 13‐year‐old patient
- A novel variant BCL11B mutation in a pediatric patient with difficult‐to‐treat eosinophilic esophagitis
- Meckel’s diverticulum: A challenging diagnosis
- Malnutrition‐related cardiomyopathy in a pediatric patient with autism spectrum disorder
- Lateral flow test versus enzyme‐linked immunosorbent assay to measure infliximab trough concentrations: A head‐to‐head comparison
- The current research status and progress of the impact of Lactobacillus on intestinal diseases
- Update on the 2024 Guidelines by Indian Society of Pediatric Gastroenterology, Hepatology and Nutrition (ISPGHAN) on the Diagnosis and Management of Pediatric Acute Liver Failure
Word Documents:
- Efficacy of vedolizumab and ustekinumab in pediatric-onset inflammatory bowel disease: A real-world multicenter study
- Esophagitis, treatment outcomes, and long-term follow-up in children with esophageal atresia
- Gastrointestinal manifestations of Rett syndrome: An updated analysis using the Gastrointestinal Health Questionnaire
- Impact of acid blocker therapy on growth, gut microbiome, and lung disease in young children with cystic fibrosis
- Food insecurity impacts diet quality and adherence to the gluten-free diet in youth with celiac disease
- Natural course and outcomes of children with ubiquitin-specific protease 53 (USP53)-related genetic chronic cholestasis
September 2024 Journal Scan
- Glycaemic control metrics and metabolic dysfunction–associated steatotic liver disease in children and adolescents with type 1 diabetes
- Gut microbiota alterations and associations with nutrients in children with celiac disease
- Increased enteral lipid supplementation is not associated with weight gain in extremely preterm infants with sufficient energy intakes
- Drugs in focus: Botulinum toxin in the therapy of gastrointestinal disorders in children
- Growth pattern of paediatric patients affected by cow milk protein allergy fed with rice hydrolyzed formula
- Management and outcomes of histoplasmosis in youth with inflammatory bowel disease in an endemic area
- Endoscopic diagnosis of asymptomatic appendicitis in a pediatric patient
- Contaminated well water driving D‐lactic acidosis in child with short bowel syndrome
- Systemic lupus erythematosus: An imitator for inflammatory bowel disease
- Disorders of gut–brain interaction through the lens of polyvagal theory
- Retrospective review of growth in pediatric intestinal failure after weaning from parenteral nutrition
- Fecal bile acid profiles before and after fecal microbial transplant in pediatric onset ulcerative colitis
- Long‐term gastrointestinal morbidity in patients born with gastroschisis: A national register‐based cohort study
- Conflict between parents, physicians, and healthcare professionals in medical decision‐making: How to address it—A systematic review from the ESPGHAN Ethics Committee
- Same-Day Repeatability and 28-Day Reproducibility of Xenon MRI Ventilation in Children With Cystic Fibrosis in a Multi-Site Trial
- Practice Recommendations for Metabolic Dysfunction–Associated Steatotic Liver Disease by the Indian Society of Pediatric Gastroenterology, Hepatology and Nutrition (ISPGHAN)
August 2024 Journal Scan
PDFs:
- Pediatric to adult transition care in neurogastroenterology and motility: A position paper from the American Neurogastroenterology and Motility Society and European Society of Neurogastroenterology and Motility
- Association of paediatric autoimmune cytopenia and inflammatory bowel disease suggests a common genetic origin
- Familial chylomicronemia syndrome: a novel mutation in the lipoprotein lipase gene
- Evaluation of gastroschisis feeding protocol: A retrospective cohort study
- Diagnosis of Hirschsprung disease by analyzing acetylcholinesterase staining using artificial intelligence
- The intestinal microbiome of infants with cow’s milk‐induced FPIES is enriched in taxa and genes of enterobacteria
- Updated joint ESPGHAN/NASPGHAN guidelines for management of Helicobacter pylori infection in children and adolescents (2023)
- Four intestinal ultrasound scores and bowel wall thickness alone correlated well with pediatric ulcerative colitis disease activity
- Adeno‐associated viral vector gene therapy: Challenges for the paediatric hepatologist
- Anorectal physiology and colonic motility in children with a history of tethered cord syndrome
Word Documents:
- Pediatric to adult transition care in neurogastroenterology and motility: A position paper from the American Neurogastroenterology and Motility Society and European Society of Neurogastroenterology and Motility
- Role of artificial intelligence in Crohn’s disease intestinal strictures and fibrosis
- Transitions of care for adolescents with disorders of gut–brain interaction
- Wilson’s disease in Sardinian population: The experience of a pediatric referral center
- Delay in diagnosis is associated with decreased treatment effectiveness in children with rumination syndrome
- Eicosatetraynoic Acid Regulates Pro-Fibrotic Pathways in an Induced Pluripotent Stem Cell Derived Macrophage:Human Intestinal Organoid Model of Crohn’s Disease
- Helicobacter pylori Antimicrobial Resistance and the Role of Next-Generation Sequencing
July 2024 Journal Scan
PDFs:
- Quality of life from childhood to adulthood: Perspectives from adult patients with pediatric‐onset intestinal failure
- Intestinal microbial and metabolite profile in infants with small bowel stomas after bowel resection
- Assessment of disease severity with magnetic resonance cholangiography in pediatric‐onset primary sclerosing cholangitis
- Adeno‐associated viral vector gene therapy: Challenges for the paediatric hepatologist
- Antibiotics, passive smoking, high socioeconomic status and sweetened foods contribute to the risk of paediatric inflammatory bowel disease: A systematic review with meta‐analysis
- Relation between the internal anal sphincter and defecation disorders in patients with anorectal malformations
- Clinical impacts of immunomodulator withdrawal from anti‐tumor necrosis factor combination therapy in pediatric inflammatory bowel disease
- A novel nutritional approach to infants and children with congenital diarrhea due to homozygous DGAT1 mutations
Word Documents:
- Prevalence and significance of autoantibodies in children with metabolic dysfunction-associated steatotic liver disease: A systematic review and meta-analysis
- Perioperative management protocol for pediatric endoluminal functional lumen imaging probe in esophageal motility disorders
- Safety and efficacy of linaclotide in children aged 2–5 years with functional constipation: Phase 2, randomized study
- Clinical characteristics and outcomes of pediatric patients with autoimmune gastritis
- Different infliximab induction dosing regimens do not affect remission rates up to 1 year in children with Crohn’s disease
June 2024 Journal Scan
PDFs:
- Early diet and the risk of coeliac disease. An update 2024 position paper by the ESPGHAN special interest group on coeliac disease
- Co‐occurrence of collagenous gastrointestinal disease in siblings in early childhood: New insight into a rare condition
- A case of Burkitt Lymphoma discovered by digital rectal exam
- Long‐term teduglutide associated with improved response in pediatric short bowel syndrome‐associated intestinal failure
- Assessing the correlation between fecal calprotectin, blood markers and disease activity in pediatric inflammatory bowel disease
- Characteristics of chronic enteropathy associated with SLCO2A1 gene (CEAS) in children, a unique type of monogenic very early-onset inflammatory bowel disease
- Current practice in the care of children with functional constipation: What is the hold up?
- Laparoscopic Warshaw procedure in pediatric solid pseudopapillary neoplasm of the pancreas: Technical feasibility and oncological outcomes
Word Documents:
- Goodbye, NAFLD, hello, MASLD?!
- Investigating the impact of elexacaftor/tezacaftor/ivacaftor therapy on longitudinal oropharyngeal microbiome dynamics in children with cystic fibrosis
- Performance of Baveno VII criteria for the screening of varices needing treatment in patients with biliary atresia
- Renal impairment is prevalent in pediatric NAFLD/MASLD and associated with disease severity
- Acute pancreatitis in children with inflammatory bowel disease: Risk factors, clinical course, and prognosis
- Association between celiac disease and pneumococcal infections in hospitalized pediatric patients in the United States
- Diagnosis and management of eosinophilic esophagitis in children: An update from the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN)
May 2024 Journal Scan
- Editing combined multichannel intraluminal impedance and pH monitoring tracings
- Standardizing steroid protocols for newly diagnosed inflammatory bowel disease patients: A quality improvement initiative
- Pilot and feasibility of the SMART IBD mobile app to improve self‐management in pediatric inflammatory bowel disease
- Outcome in pediatric celiac disease is independent of the diagnostic approach in patients with high antibody levels
- Manometric findings in children with eosinophilic esophagitis and persistent post‐remission dysphagia
- Lactase for infantile colic: A systematic review of randomized clinical trials
- Juvenile polyposis syndrome in children: The impact of SMAD4 and BMPR1A mutations on clinical phenotype and polyp burden
- Infant formulas for the treatment of functional gastrointestinal disorders: A position paper of the ESPGHAN Nutrition Committee
- Impact of medication dosage on Helicobacter pylori eradication rates among pediatric patients
- Complex Decision-Making for Gastroesophageal Reflux in Children With Neurologic Impairment
- Clinical validation and accuracy assessment of the Capsule Endoscopy‐Crohn’s Disease index (CE‐CD)
- Variation in care for inpatients with avoidant restrictive food intake disorder leads to development of a novel inpatient clinical pathway to standardize care
- Utility of colonic manometry in children with Hirschsprung disease
- Ustekinumab in paediatric patients with moderately to severely active Crohn’s disease: UniStar study long‐term extension results
April 2024 Journal Scan
- Safety and efficacy of elexacaftor/tezacaftor/ivacaftor in people with Cystic Fibrosis following liver transplantation: A systematic review
- Monitoring pediatric eosinophilic esophagitis disease activity using an unsedated blind esophageal brushing model: A pilot study
- Persistent and newly developed gastrointestinal symptoms after surgery for intestinal malrotation in children: Dysmotility or disorders of gut and brain interaction?
- Prebiotics in the management of pediatric gastrointestinal disorders: Position paper of the ESPGHAN special interest group on gut microbiota and modifications
- Role of high‐volume plasmapheresis in the management of paediatric acute liver failure
- The trends of pediatric duodenal ulcer and predictors of recurrence
- Transanal irrigation in children with functional constipation: A systematic review and meta‐analysis
- A multicenter registry study on percutaneous electrical nerve field stimulation for pediatric disorders of gut–brain interaction
- A serum‐induced gene signature in hepatocytes is associated with pediatric nonalcoholic fatty liver disease
- Catalyzing change: Implementing standardised reporting in monogenic inflammatory bowel disease research
- Efficacy of lubiprostone for functional constipation treatment in adolescents and children: Randomized controlled trial
- ESPGHAN recommendations on treatment of chronic hepatitis C virus infection in adolescents and children including those living in resource‐limited settings
- Genetic and acquired sucrase‐isomaltase deficiency: A clinical review
- Gluten‐free diet for pediatric patients with coeliac disease: A position paper from the ESPGHAN gastroenterology committee, special interest group in coeliac disease
- Esophago‐gastric junction findings on high resolution impedance manometry in children with esophageal atresia
March 2024 Journal Scan
- An ESPGHAN Position Paper on the Diagnosis, Management, and Prevention of Cow’s Milk Allergy
- Precision nutrition in pediatric IBD: A position paper from the ESPGHAN special interest group for basic science and translational research, the IBD Porto group, and allied health professionals
- Impact of COVID‐19 on paediatric chronic intestinal failure: A tertiary care children’s hospital experience
- Paediatric steatotic liver disease has unique characteristics: A multisociety statement endorsing the new nomenclature
- Radiopaque marker colonic transit study in the pediatric population BSPGHAN Motility Working Group consensus statement
- Real‐world effectiveness of ustekinumab and vedolizumab in TNF‐exposed pediatric patients with ulcerative colitis
- The prevalence of rumination syndrome and rumination disorder: A systematic review and meta-analysis
- Vitamin B12 deficiency in over 16s: diagnosis and management
- Clinical trial: Randomized controlled trial of linaclotide in children aged 6−17 years with functional constipation
- Etrasimod as induction and maintenance therapy for ulcerative colitis (ELEVATE): two randomised, double-blind, placebo-controlled, phase 3 studies
- Parenteral nutrition emulsion inhibits CYP3A4 in an iPSC derived liver organoids testing platform
- Pediatric retrograde cricopharyngeal dysfunction diagnosed by high‐resolution impedance manometry
- Transanal irrigation in children with functional constipation: A systematic review and meta‐analysis
February 2024 Journal Scan
- The role of high‐resolution impedance manometry to identify rumination syndrome in children with unexplained foregut symptoms
- Using social media for patient care, research, and professional development: A North American Society of Pediatric Gastroenterology, Hepatology, and Nutrition position paper
- Effect of lactase supplementation on infant colic: Systematic review of randomized controlled trials
- Endoscopist experience with pediatric recurrent and intentional foreign body ingestion (RIFBI): Management considerations and future directions
- ESPGHAN recommendations on treatment of chronic hepatitis C virus infection in adolescents and children including those living in resource‐limited settings
- Genetic and acquired sucrase‐isomaltase deficiency: A clinical review
- Histopathological findings from the investigation of paediatric acute hepatitis of unknown aetiology
- Gluten‐free diet for pediatric patients with coeliac disease: A position paper from the ESPGHAN gastroenterology committee, special interest group in coeliac disease
- Pediatricians’ practices and knowledge of metabolic dysfunction‐associated steatotic liver disease: An international survey
- Prebiotics in the management of pediatric gastrointestinal disorders: Position paper of the ESPGHAN special interest group on gut microbiota and modifications
- Faecal microbiota transplantation in children: A systematic review
- Nutritional management of high-output ileostomies in paediatric patients is vital and more evidence-based guidelines are needed
- Towards a Standardized Classification of the Hepatobiliary Manifestations in Cystic Fibrosis (CFHBI): A Joint ESPGHAN/NASPGHAN Position Paper
- An ESPGHAN Position Paper on the Diagnosis, Management, and Prevention of Cow’s Milk Allergy
- Catalyzing change: Implementing standardised reporting in monogenic inflammatory bowel disease research
- Joint ESPGHAN/NASPGHAN Guidelines on Childhood Eosinophilic Gastrointestinal Disorders Beyond Eosinophilic Esophagitis
- Novel pharmacological developments in the management of paediatric inflammatory bowel disease: Time for guideline update – A narrative review
- Proton pump inhibitors, antibiotics, and atopy increase the risk of eosinophilic esophagitis in children with esophageal atresia
January 2024 Journal Scan
- High faecal pH and low total microbial load associate with normalisation of faecal calprotectin in children with Crohn’s disease treated with exclusive enteral nutrition; results from iPENS, a multicentre, prospective study
- Human germline heterozygous gain-of-function STAT6 variants cause severe allergic disease
- Mechanisms and functions of intestinal vascular specialization
- Safety of the One Step Percutaneous Endoscopic Gastrostomy (Push-PEG) Button in Pediatric Patients
- Efficacy and safety of Adalimumab in Very Early-onset IBD – A Multicentre Study from the Paediatric IBD Porto Group of ESPGHAN
- A novel memory-like Tfh cell subset is precursor to effector Tfh cells in recall immune responses
- Causes and Outcome of Central Venous Catheter Repair in Children with Intestinal Failure on Home Parenteral Nutrition
- Could Urinary Copper/Zinc Ratio Be a Newer Tool to Replace 24-Hour Urinary Copper Excretion for Diagnosing Wilson Disease in Children? – PMC
- Developmental Feeding Stages and Their Impact on Child Feedi… : Journal of Pediatric Gastroenterology and Nutrition
- Efficacy and safety of linaclotide in treating functional constipation in paediatric patients: a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial – The Lancet Gastroenterology & Hepatology
- Hypnotherapy in Pediatric Gastroenterology
- NOD2 Polymorphisms May Direct a Crohn Disease Phenotype in Patients with Very Early-Onset Inflammatory Bowel Disease
- Presentation, characteristics and management of obstructive intestinal conditions in cystic fibrosis
November 2023 Journal Scan
- New horizons of human genetics in digestive diseases
- Practical multidisciplinary framework for the assessment and management of patients with unexplained chronic aerodigestive symptoms
- Precision Medicine in Monogenic Inflammatory Bowel Disease: proposed mIBD REPORT standards
- Gastric Intestinal Metaplasia: Real Culprit or Innocent Bystander as a Precancerous Condition for Gastric Cancer?
- Approaches for greening endoscopy and reducing waste
- Adalimumab in Biologic-naı¨ve Patients With Crohn’s Disease After Resolution of an Intra-abdominal Abscess: A Prospective Study From the GETAID
- AGA Clinical Practice Guideline on the Role of Biomarkers for the Management of Crohn’s Disease
- AGA Clinical Practice Update on the Role of Artificial Intelligence in Colon Polyp Diagnosis and Management: Commentary
- Global Incidence and Prevalence of Eosinophilic Esophagitis, 1976–2022: A Systematic Review and Meta-analysis
- Helicobacter pylori Antimicrobial Resistance in a Pediatric Population From the New England Region of the United States
- Conserved γδ T cell selection by BTNL proteins limits progression of human inflammatory bowel disease
- Refeeding Syndrome in Pediatric Age, An Unknown Disease: A Narrative Review
- Management of chronic HBV‐HDV patients chronic HBV‐HDV infection: A review on new management options
- Review article: Updated management of acute severe ulcerative colitis: From steroids to novel medical strategies
- Gut microbiota signatures in inflammatory bowel disease
October 2023 Journal Scan
- Horizon scanning: new and future therapies in the management of inflammatory bowel disease
- Opportunities and challenges for hepatitis B cure
- Metabolic Sequelae: The Pancreatitis Zeitgeist of the 21st Century
- AGA Clinical Practice Update on the Epidemiology, Evaluation, and Management of Exocrine Pancreatic Insufficiency: Expert Review
- HLA-DQA1*05 Genotype and Immunogenicity to Tumor Necrosis Factor-a Antagonists: A Systematic Review and Meta-analysis
- Persistent villous atrophy predicts development of complications and mortality in adult patients with coeliac disease: a multicentre longitudinal cohort study and development of a score to identify highrisk patients
- Postendoscopy Care for Patients Presenting With Esophageal Food Bolus Impaction: A Population-Based Multicenter Cohort Study
- Efficacy of Probiotics in Irritable Bowel Syndrome: Systematic Review and Meta-analysis
- Real-World Experience With Tofacitinib Dose De-Escalation in Patients With Moderate and Severe Ulcerative Colitis
- Update on Endoscopic Dysplasia Surveillance in Inflammatory Bowel Disease
- Review article: Updated management of acute severe ulcerative colitis: From steroids to novel medical strategies
- A pilot genome-wide association study meta-analysis of gastroparesis
September 2023 Journal Scan
- A mechanism by which gut microbiota elevates permeability and inflammation in obese/diabetic mice and human gut
- Consensus definition of sludge and microlithiasis as a possible cause of pancreatitis
- Post-operative prevention and monitoring of Crohn’s disease recurrence
- Stem cell therapy: light in the tunnel for penetrating Crohn’s disease
- Clinical and genetic determinants of severe acute pancreatitis: A genetic association study in the UK Biobank
- Enterochromaffin Cells: Small in Number but Big in Impact
- Psychological Processes, Not Physiological Parameters, Are Most Important Contributors to Symptom Severity in Patients With Refractory Heartburn/Regurgitation Symptoms
- The efficacy and safety of thalidomide in the treatment of refractory Crohn’s disease in adults: a double-center, double-blind, randomized–controlled trial
- Immunomodulators: still having a role?
- An update on the management of non-variceal upper gastrointestinal bleeding
- Steps Toward a Greener Endoscopy Unit
- Optimizing the Utility of Anorectal Manometry for Diagnosis and Therapy: A Roundtable Review and Recommendations
- Preclinical Serological Signatures are Associated With Complicated Crohn’s Disease Phenotype at Diagnosis
- Microbiota-derived butyrate dampens linaclotide stimulation of the guanylate cyclase C pathway in patient-derived colonoids
- Longitudinal Fecal Calprotectin Profiles Characterize Disease Course Heterogeneity in Crohn’s Disease
- Irritable bowel syndrome and mental health comorbidity — approach to multidisciplinary management
- The impact of primary peristalsis, contractile reserve, and secondary peristalsis on esophageal clearance measured by timed barium esophagogram
- How to effectively use and interpret the barium swallow: Current role in esophageal dysphagia
- Improved diagnosis of reflux hypersensitivity
- Single-cell atlas of the human neonatal small intestine affected by necrotizing enterocolitis
- Clinical Effect of Mirikizumab Treatment on Bowel Urgency in Patients with Moderately to Severely Active Ulcerative Colitis and the Clinical Relevance of Bowel Urgency Improvement for Disease Remission
- Pediatric Drug-Associated Pancreatitis Reveals Concomitant Risk Factors and Poor Reliability of Causality Scoring: Report From INSPPIRE
DOI: 10.1097/MPG.0000000000003898 - CFTR Modulators for the Gastroenterologist
DOI: 10.1097/MPG.0000000000003904 - Interleukin-22 suppresses major histocompatibility complex II in mucosal epithelial cells
July 2023 Journal Scan
- Development of a Practical Guide to Implement and Monitor Diet Therapy for Eosinophilic Esophagitis
- Differential Diagnosis of Chronic Diarrhea – An Algorithm to Distinguish Irritable Bowel Syndrome With Diarrhea From Other Organic Gastrointestinal Diseases, With Special Focus on Exocrine Pancreatic Insufficiency
- Minimally invasive endoscopic therapies for gastro-oesophageal reflux disease
- Bile acids and their receptors: Potential therapeutic targets in inflammatory bowel disease
- Comparative Effectiveness of Anti-TNF in Combination With Low-Dose Methotrexate vs Anti-TNF Monotherapy in Pediatric Crohn’s Disease: A Pragmatic Randomized Trial
- Dupilumab: The New Kid on the Block for Management of Eosinophilic Esophagitis
- Filgotinib for the Treatment of Small Bowel Crohn’s Disease: The DIVERGENCE 1 Trial
- The management of adult patients with severe chronic small intestinal dysmotility
- Pediatric Intestinal Pseudo-Obstruction: Progress and Challenges
- The Role of a Colon-in-Continuity in Short Bowel Syndrome
- Nutritional Management of Intestinal Failure due to Short Bowel Syndrome in Children
- Enteric Neuromyopathies: Highlights on Genetic Mechanisms Underlying Chronic Intestinal Pseudo-Obstruction
- Defining Interactions Between the Genome, Epigenome, and the Environment in Inflammatory Bowel Disease: Progress and Prospects
- Is the Quantification of Interstitial Cells of Cajal in Gastric Biopsy Samples in Patients With Gastroparesis Ready for Prime Time?
June 2023 Journal Scan
- BAPEN / BIFA Guidelines on the Diagnosis and Management of Intestinal Failure Associated Liver Disease (IFALD)
- Extracellular Vesicles in Transplantation
- Mesenchymal Stem Cell-Derived Secretome: A Potential Therapeutic Option for Autoimmune and Immune-Mediated Inflammatory Diseases
- The Unique Immunomodulatory Properties of MSC-Derived Exosomes in Organ Transplantation
- Artificial Intelligence Applications in Hepatology
March 2023 Journal Scan
PDFs:
- Comparative Risk of Serious Infections With Biologic Agents and Oral Small Molecules in Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis
- Management of Pancreatic Fluid Collections – An Evidence-based Approach
- World Journal of Gastroenterology – Precision medicine in inflammatory bowel disease: Individualizing the use of biologics and small molecule therapies
- Improving IBD outcomes in the era of many treatment options
- Towards Improving Diagnosis of Dyssynergic Defecation: A Small Step or a New Paradigm?
- High Discovery Rate of Duodenal and Gastric Eosinophilia in Patients With Unexplained Moderate–Severe Abdominal Symptoms: A Prospective US Multisite Study
- Clinical Implications of Low-grade Duodenal Eosinophilia in Functional Dyspepsia – A Prospective Real-life Study
- Complications and Utility of Gastrointestinal Endoscopy Post Hematopoietic Stem Cell Transplantation: An 11 Year Experience
- Evaluation and Management of Postsurgical Patient With Hirschsprung Disease Neurogastroenterology & Motility Committee: Position Paper of North American Society of Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN)
- Fecal Microbiota Transplantation Across the Lifespan: Balancing Efficacy, Safety, and Innovation
- Understanding neuroimmune interactions in disorders of gut–brain interaction: from functional to immunemediated disorders
- Pediatric-to-Adult Transfer of Care in Patients With Pancreas Disease: Recommendations for Care and Research Opportunities
- Microbial transmission, colonisation and succession: from pregnancy to infancy
Word Documents:
- Exocrine pancreatic dysfunction in IBD
- Pathogenic TRPV6 variants increase the risk of recurrent acute pancreatitis or chronic pancreatitis in children
- Antibiotic lock solutions prevent CRBSI – a systematic review
- Diagnostic yield of routine biopsies in Paediatric Gastrointestinal Endoscopy
- Gastrointestinal Endoscopy post HSCT
- Treatment of Rumination syndrome in children
- Dupilumab, A monoclonal antibody for the treatment of eosinophilic oesophagitis
- Efficacy and Safety of Drugs for Gastroparesis: Systematic Review
February 2023 Journal Scan
- Drug Treatments for Gastroparesis—Why Is the Cupboard So Bare?
- Advances in Acute and Chronic Pancreatitis
- Minimally invasive endoscopic therapies for gastro-oesophageal reflux disease
- The role of high serum triglyceride levels on pancreatic necrosis development and related complications
- IV Fluids in Pancreatitis
- Drugs for Celiac Disease
- Coproduced resources to support parents caring for children with gastrostomies
- Post COVID IBS
- Probiotics for the Management of Pediatric Gastrointestinal Disorders: Position Paper of the ESPGHAN Special Interest Group on Gut Microbiota and Modifications
- Effect of Ramadan intermittent fasting on inflammatory markers, disease severity, depression, and quality of life in patients with inflammatory bowel diseases: A prospective cohort study
- Aetiology, diagnosis and management of small intestinal bacterial overgrowth
Historical articles of interest suggested by the Editor of Frontline Gastroenterology:
- Aetiology, diagnosis and management of small intestinal bacterial overgrowth
- Anorexia nervosa and the gastrointestinal tract
- Diagnostic ileocolonoscopy: getting the basics right
- Gastrointestinal symptoms and nutritional issues in patients with hypermobility disorders: assessment, diagnosis and management
- Management of Crohn’s stricture: medical, endoscopic and surgical therapies
January 2023 Journal Scan
- AASLD practice guidance on primary sclerosing cholangitis and cholangiocarcinoma
- Enteral Nutrition in Preterm Infants (2022): A Position Paper From the ESPGHAN Committee on Nutrition and Invited Experts
- Faecal microbiota transplantation with anti-inflammatory diet (FMT-AID) followed by anti-inflammatory diet alone
- Promote or Prevent? Gut Microbial Function and Immune Status May Determine the Effect of Fiber in Inflammatory Bowel Disease
- Gastrointestinal symptoms and nutritional issues in patients with hypermobility disorders: assessment, diagnosis and management
- Understanding neuroimmune interactions in disorders of gut–brain interaction: from functional to immunemediated disorders
- Intestinal Ultrasound for the Pediatric Gastroenterologist: A Guide for Inflammatory Bowel Disease Monitoring in Children
- Natural history of liver disease in a large international cohort of children with Alagille syndrome: Results from the GALA study
- Probiotics for the Management of Pediatric Gastrointestinal Disorders: Position Paper of the ESPGHAN Special Interest Group on Gut Microbiota and Modifications
- Rare, Overlooked, or Underappreciated Causes of Recurrent Abdominal Pain: A Primer for Gastroenterologists